Rajendra Pangeni, Ph.D.
Assistant Professor of Genomics, Institute for Neuro-Immune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University
Dr. Rajendra Pangeni, completed his PhD in molecular oncology from the University of Wolverhampton, UK. During his PhD, he worked on DNA methylation dysregulation in breast cancer metastases to the brain using genome wide and laboratory approaches. He received his post-doctoral trainings from Northwestern University Chicago and City of Hope National Medical Center, Duarte, California. During his post doctoral works, Dr. Pangeni worked on glioblastoma (one of the most aggressive brain tumors) and non-small cell lung cancer using genome wide DNA methylation array, RNA sequencing, stem cells, mouse models, and other genetic and epigenetics approaches.
At Nova Southeastern University, Dr. Pangeni is working on identifying genes that could be used as potential biomarkers and therapeutic targets in Gulf War illness, chronic fatigue syndrome (CFS), cancer and other genetic/epigenetic diseases. He uses single cell transcriptomics, whole-genome bisulfite sequencing, and other state-of-the-art technologies and laboratory approaches.
Research Interests
Cancer and metastases, stem cells, Gulf war Illness, Chronic Fatigue Syndrome (CFS), Biomarkers, Experimental therapeutics, genomics and epigenomics.
2022
- Genome-wide methylation analyses identifies non-coding RNA genes dysregulated in breast tumours that metastasise to the brain Rajendra P. Pangeni, David Huen, Vannessa C. Buzatto, Tracy J Warr, Mark R Morris et al (2022). Scientific Reports. 12:1102.
2020
- G9a Promotes Invasion and Metastasis of Non-Small Cell Lung Cancer through Enhancing Focal Adhesion Kinase Activation via NF-κB Signaling Pathway Sun T, Zhang K, Pangeni RP, Wu J, Li W, Du Y, Guo Y, Chaurasiya S, Arvanitis L, Raz DJ. Mol Cancer Res. 2021 Mar;19(3):429-440. doi: 10.1158/1541-7786.MCR-20-0557. Epub 2020 Dec 9. PMID: 33298547; PMCID: PMC8785801.
2018
- Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma. Pangeni RP, Zhang Z, Alvarez AA, Wan X, Sastry N, Lu S, Shi T, Huang T, Lei CX, James CD, Kessler JA, Brennan CW, Nakano I, Lu X, Hu B, Zhang W, Cheng SY. Epigenetics. 2018;13(4):432-448. doi: 10.1080/15592294.2018.1469892. Epub 2018 Aug 6. PMID: 29927689; PMCID: PMC6140806.
2017
- MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma Huang T, Kim CK, Alvarez AA, Pangeni RP, Wan X, Song X, Shi T, Yang Y, Sastry N, Horbinski CM, Lu S, Stupp R, Kessler JA, Nishikawa R, Nakano I, Sulman EP, Lu X, James CD, Yin XM, Hu B, Cheng SY. Cancer Cell. 2017 Dec 11;32(6):840-855.e8. doi: 10.1016/j.ccell.2017.11.005. PMID: 29232556; PMCID: PMC5734934.
2015
- The GALNT9, BNC1 and CCDC8 genes are frequently epigenetically dysregulated in breast tumours that metastasise to the brain Pangeni RP, Channathodiyil P, Huen DS, Eagles LW, Johal BK, Pasha D, Hadjistephanou N, Nevell O, Davies CL, Adewumi AI, Khanom H, Samra IS, Buzatto VC, Chandrasekaran P, Shinawi T, Dawson TP, Ashton KM, Davis C, Brodbelt AR, Jenkinson MD, Bièche I, Latif F, Darling JL, Warr TJ, Morris MR. Clin Epigenetics. 2015 May 27;7(1):57. doi: 10.1186/s13148-015-0089-x. PMID: 26052355; PMCID: PMC4457099.
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