E.M. Papper Laboratory of Clinical Immunology

The E. M. Papper Laboratory of Clinical Immunology, directed by Dr. Kristina Aenlle, has been at the forefront of research and clinical care for over 30 years. With laboratory facilities at NSU’s Davie Campus and the Miami VA Medical Center, our laboratories are licensed clinical reference labs in the State of Florida, CLIA-certified, and National Institutes of Health (NIH), U.S. Department of Veterans Affairs (VA), and Department of Defense-funded research facilities.

Pioneering Neuro-Immune Research

The E.M. Papper Laboratory is a testament to the pioneering work and unwavering dedication of Dr. Mary Ann Fletcher, its former director. As the inaugural Schemel Professor for Neuro-Immune Medicine at the Dr. Kiran C. Patel College of Osteopathic Medicine, Dr. Fletcher's contributions to the field of immunology and infectious diseases have been widely recognized.

Her extensive research, which spanned decades at the University of Miami and the Institute for Neuro-Immune Medicine at NSU, focused on proteomic and genomic studies. The E.M. Papper Laboratory, a legacy of her tenure at Miami, continues to be a cornerstone of research excellence.

Laboratory Services

NSU’s E.M. Papper Laboratory of Clinical Immunology is an independent lab and offers a range of diagnostic tests, including:

Flow Cytometry
Natural Killer Cell Toxicity
Multiplex Cytokines
EBV Viral Load Assays

We also conduct gene expression research using the NanoString Analyser.

Physicians may send samples to the lab for testing. For a comprehensive list of lab services, pricing inquiries, procedures, and general questions, please email EMPapper@nova.edu.

View Sample of Laboratory Tests Offered

TEST	Description	CPT
Immunoglobulin Quantitation	IgG, IgA, IgM	82784 (x3)
Immunoglobulin Subclasses	IgG1, IgG2, IgG3, IgG4	82787 (x4)
Epstein-Barr Nuclear Antigen (EBNA)	IgG	86664
Epstein-Barr Virus Early Antigen (EB-EA)	IgG	86663
Epstein-Barr Virus (VCA)	IgG	86665
Epstein-Barr Virus (VCA)	IgM	86665
Herpes Simplex Virus-2	IgG	86696
Human Herpes Virus-6	IgG	86790 (x4)
C-Reactive Protein		86140
Mulitplex 18 Cytokines Panel	IL-1a, IL-1b IL-4, IL-8, IL-13, IL-23, IL-5, IL-10, IL-15, IL-2, IL-6, IL-12, IL-17, Tumor Necrosis Factor α, Tumor Necrosis Factor β, Interferon Gamma (IFNy), TNF Receptor I, TNF Receptor II	83520 (x18)
In vitro Cytokine Induction Assay, Multiplex 18	IL-1a, IL-1b IL-4, IL-8, IL-13, IL-23, IL-5, IL-10, IL-15, IL-2, IL-6, IL-12, IL-17, Tumor Necrosis Factor α, Tumor Necrosis Factor β, Interferon Gamma (IFNy), TNF Receptor I, TNF Receptor II	86353 (x2); 83520 (x18)
Lymphocyte Activations/Differential	CD45, CD3, CD4, CD8, CD5, CD2, CD45RA, CD26, CD56, CD38, CD19, CD95, CD25, CD28, CD14, CD62L, CD11a, CD11b	88184; 88185 (x17)
ComprehensiveLymphocyte Activations/Differential & Natural Killer Cell Cytotoxicity	CD45, CD3, CD4, CD8, CD5, CD2, CD45RA, CD26, CD56, CD38, CD19, CD95, CD25, CD28, CD14, CD62L, CD11a, CD11b, Lymphocyte Culture	88184; 88185 (x17); 86353 (x4)
T-Cells and T-Cell Subsets	CD45, CD3, CD4, CD8	88184; 88185 (x3)
T-Cell Subsets and NK-Cells	CD45, CD3, CD4, CD8, CD14, CD56	88184; 88185 (x5)
T-Cell Subsets and Natural Killer Cell Cytotoxicity	CD45, CD3, CD4, CD8, CD14, CD56, Lymphocyte Culture	88184; 88185 (x5); 86353 (x4)
T-Cell Subsets and B-Cells	CD45, CD3, CD4, CD8, CD14, CD19	88184; 88185(x5)
T-Cell Subsets, B-Cells and NK Cells	CD45, CD3, CD4, CD8, CD14, CD19, CD56	88184; 88185(x6)
Comprehensive T-Cell Subsets, B-Cells and Natural Killer Cell Cytotoxicity	CD45, CD3, CD4, CD8, CD14, CD19, CD56, Lymphocyte Culture	88184; 88185(x6); 86353(x4)
Neutrophil Oxidative Burst by Flow cytometry; culture	Flow Cytometry, Culture	88184; 88185; 86353
Leukocyte Adhesion Deficiency; culture	Flow Cytometry, Culture	88184; 88185; 86353
Perforin and granzymes in NK cells and T cells by flow cytometry and culture		88184; 88185 (x5)
Comprehensive Natural Killer Cell Cytotoxicity	CD3, CD45, CD14, CD56, Lymphocyte Culture	86353 (x4); 88184; 88185(x2); 86357
Complete Blood Count (CBC)		85025
Erythrocyte Sedimentation Rate (ESR)		85651

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BioBank and Proficiency Testing Program

The E.M. Papper Laboratory also houses a biobank with emergency backup freezers and participates in the ACTG/Duke proficiency testing program, ensuring quality in the cryopreservation, storage, and shipment of blood samples.

Ensuring Patient Privacy

We are committed to protecting patient information. Providers can review our Privacy Statement and access our Privacy Practices in English, Spanish and Creole for compliance.

Meet Our Team of Experts

Directors and Managers

Nancy G. Klimas, M.D.

Director, Institute for Neuro-Immune Medicine, NSU
Professor and Chair, Department of Clinical Immunology, NSU
Assistant Dean of Research, Dr. Kiran C. Patel College of Osteopathic Medicine, NSU
Director, Environmental Medicine Research and Clinical Program Miami VA Medical Center
Professor Emerita, University of Miami, School of Medicine

Dr. Nancy Klimas has 40 years of professional experience and has achieved international recognition for her research and clinical efforts in multi-symptom disorders, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Gulf War illness (GWI), fibromyalgia, and most recently Long COVID.

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Kristina Aenlle, Ph.D.

Associate Director, E.M. Papper Laboratory of Clinical Immunology
Assistant Professor, Dr. Kiran C. Patel College of Osteopathic Medicine

Dr. Kristina Aenlle's diverse research background has taken her from the brain to the stem cell niche of the bone, always with the focus of the endocrine system signaling and aging. Her research goal is to improve and promote healthy aging by understanding the molecular changes that are occurring during aging. Alongside Drs. Klimas and Fltecher, she examines the molecular mechanism of HPA/HPG axis disruption in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Gulf War illness (GWI).

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Enriqueta Molinares
Research Lab Manager, E.M. Papper Laboratory of Clinical Immunology

Estella Sanchez Guerrero, Ph.D. and MDT

Director - Medical Laboratory, E.M. Papper Laboratory of Clinical Immunology
Assistant Professor, Dr. Kiran C. Patel College of Osteopathic Medicine

Professors

Lubov Nathanson, Ph.D.

Associate Professor, Dr. Kiran C. Patel College of Osteopathic Medicine, NSU
Voluntary Assistant Professor, Dept. of Medicine, University of Miami Miller School of Medicine

Dr. Lubov Nathanson is an experienced, versatile and multidisciplinary trained scientist with over 20 years of work experience in basic and translational genomics and proteomics research. She has a combined expertise in bioinformatics, molecular biology, biochemistry and systems biology. As an Associate Professor for the Institute for Neuro-Immune Medicine, her work involves analysis of gene expression data of microarrays and RNA-seq experiments, analyzing systems biology including metabolic pathways and gene ontology, building gene interaction networks, creating custom pathways, and searching for upstream and downstream gene interactions.

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Rajendra Pangeni, Ph.D.

Assistant Professor of Genomics, Institute for Neuro-Immune Medicine

Dr. Rajendra Pangeni, completed his PhD in molecular oncology from the University of Wolverhampton, UK. During his PhD, he worked on DNA methylation dysregulation in breast cancer metastases to the brain using genome wide and laboratory approaches. He received his post-doctoral trainings from Northwestern University Chicago and City of Hope National Medical Center, Duarte, California. During his post doctoral works, Dr. Pangeni worked on glioblastoma (one of the most aggressive brain tumors) and non-small cell lung cancer using genome wide DNA methylation array, RNA sequencing, stem cells, mouse models, and other genetic and epigenetics approaches.

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Research Assistants and Associates